In my opinion, PEMF (pulsed electromagnetic fields) is one of the most exciting technologies in all of energy medicine, wellness and anti-aging. Simply because it flat out WORKS, naturally and non-invasively There are now in the tens of thousands of studies validating its efficacy from A-Z varying conditions.
PEMF stands for Pulsed ElectroMagnetic Fields and PEMFs are magnetic fields that change with time, or sometimes called time varying magnetic fields.
PEMF is Natural and all around us in the Earth's Geomagnetic fields and Schumann resonances.
PEMF therapy uses pulsating magnetic fields generated by electromagnetics and are controlled by a signal generator. As we'll see at the end these changing magnetic fields, when done right, have signals that can affect tremendous healing and regeneration.
And as I show in my book, PEMF is an essential element of health! Body mind earth, zero field studies.
PEMF has been gaining increased acceptance, in 2011, the Dr OZ show had an entire episode on PEMF for relieving pain saying it was one of greatest breakthroughs in pain management he had ever seen.
And I have to agree which is the topic of my talk today. Working with thousands of people over the last 15 years in PEMF, I would say pain relief is the number one reason why people get a pemf device and the number one testimonial I have received because it flat out works.
PEMF stands for Pulsed ElectroMagnetic Fields and PEMFs are magnetic fields that change with time, or sometimes called time varying magnetic fields.
PEMF is Natural and all around us in the Earth's Geomagnetic fields and Schumann resonances.
PEMF therapy uses pulsating magnetic fields generated by electromagnetics and are controlled by a signal generator. As we'll see at the end these changing magnetic fields, when done right, have signals that can affect tremendous healing and regeneration.
And as I show in my book, PEMF is an essential element of health! Body mind earth, zero field studies.
PEMF has been gaining increased acceptance, in 2011, the Dr OZ show had an entire episode on PEMF for relieving pain saying it was one of greatest breakthroughs in pain management he had ever seen.
And I have to agree which is the topic of my talk today. Working with thousands of people over the last 15 years in PEMF, I would say pain relief is the number one reason why people get a pemf device and the number one testimonial I have received because it flat out works.
How common is chronic pain?
Acute pain is fairly obvious in that it occurs suddenly from an accident, injury, surgery, tooth extraction, etc.
Chronic pain is pain that lasts, or comes and goes, over multiple months or years (usually any pain lasting for more than 3 months). It may result from a variety of health conditions, such as arthritis, fibromyalgia, chronic migraine, or cancer. Some people also experience chronic pain following an injury, even after the initial injury has healed.
The National Health Interview SurveyTrusted and CDC Reported
Between 2019 and 2021, the prevalence of chronic pain among U.S. adults ranged from 20.5% to 21.8%, and the prevalence of high-impact chronic pain ranged from 6.9% to 7.8% (Figure). During 2021, an estimated 51.6 million U.S. adults (20.9%) experienced chronic pain, and 17.1 million (6.9%)
Chronic Pain - 70-80 Million
Diabetes 37 Million
Heart Disease
Cancer
Stroke
7% Limited activities at work an in life.
Acute pain is fairly obvious in that it occurs suddenly from an accident, injury, surgery, tooth extraction, etc.
Chronic pain is pain that lasts, or comes and goes, over multiple months or years (usually any pain lasting for more than 3 months). It may result from a variety of health conditions, such as arthritis, fibromyalgia, chronic migraine, or cancer. Some people also experience chronic pain following an injury, even after the initial injury has healed.
The National Health Interview SurveyTrusted and CDC Reported
Between 2019 and 2021, the prevalence of chronic pain among U.S. adults ranged from 20.5% to 21.8%, and the prevalence of high-impact chronic pain ranged from 6.9% to 7.8% (Figure). During 2021, an estimated 51.6 million U.S. adults (20.9%) experienced chronic pain, and 17.1 million (6.9%)
Chronic Pain - 70-80 Million
Diabetes 37 Million
Heart Disease
Cancer
Stroke
7% Limited activities at work an in life.
What is pain and why do we feel it?
Pain is an unpleasant sensory and emotional experience, associated with actual or potential tissue damage.
Pain is vital to humans because it signals that something is wrong. Pain is not a disease, but rather it’s an important warning sign to protect the body. But pain CAN be the result of Chronic diseases such as cancer and heart disease. Because Pain is something we experience, it's best measured by what you say it is.
Pain has an intensity; you can describe it on a scale from zero, no pain, to ten, the most pain imaginable. But pain also has a character,like sharp, dull, burning, or aching.
What exactly creates these perceptions of pain?
Well, when you get hurt, special tissue damage-sensing nerve cells, called nociceptors, fire and send signals to the spinal cord and then up to the brain. These are called pain signals.
The brain responds to these pain signals and has to cope with them in various ways. The most immediate being motor pathways are activated almost instantly to take your hand off a hot stove, for example. Also inflammatory cytokines trigger your blood vessels to dilate and increase blood flow, signaling immune cells, hormones and nutrients into the injury site to aid in healing.
Pain modulation networks are also activated that deliver endorphins and enkephalins, chemicals released when you're in pain or during extreme exercise, creating the runner's high or feelings of joy and happiness. For example laughter has also been proven to increase endorphins. Endorphins bind to opioid receptor sites and give us that feel good response that quells the pain and also helps to prevent further tissue damage. But the key idea here is the Body Can Make its Own Endorphins!
----
Chronic pain can interfere with your daily activities, such as working, having a social life and taking care of yourself or others. It can lead to depression, anxiety and trouble sleeping, which can make your pain worse. This response creates a cycle that’s difficult to break.
So anything that can help get rid of chronic pain naturally, safe and effectively- like PEMF therapy - can be a total life changing breakthrough if you have chronic pain as it can and does dramatically improve your quality of life!
---
Some of the MOST COMMON Sources of PAIN
When asked about four common types of pain, respondents of a National Institute of Health Statistics survey indicated that
1) low back pain was the most common (27%),
2) severe headache or migraine pain (15%),
3) neck pain (15%)
4) and facial ache or pain (4%). (mouth , teeth, jaw, eyes)
5) Joint Pain
6) Neuropathic Pain
7) Functional Pain
------
Conventional Medicine Approaches: heavy medication, procedures, surgeries, and physical therapy (physical therapy best acute pain).
Most people reach for a simple Numbing (like topical numbing creams and ice) and Dumbing approach to pain, like OTC, Prescriptions Opioids, or steroid injections and even antidepressents and sedatives/tranquilizers.
For mild pain, non-prescription medications OTC
can act on cells where the pain signals start. Examples are aspirin, acetominaphin (Tylenol) and ibuprofen (Advil), and naproxen - Nuh-praak-sin(Aleve).
For most this is not good enough. 16,000 Americans a year with arthritis alone die from gastric bleeding from nonsteroidal antiinflammatories like aspirin and ibuprofen. Thousands of others have permanent kidney damage from the NSAIDs.
Other stronger pain medicines and anesthetics work by reducing the activity in pain-sensing circuits or boosting our coping system, or endorphins. Oxycontin, Vicodine, Percoset and Morphine. (note Percoset and Vicodin both have acetominphin so double the issues.
It is these opioids that mimic endorphin that are such a problem that are incredibly addictive and have led to a nationwide Opioid crisis.
Pain is an unpleasant sensory and emotional experience, associated with actual or potential tissue damage.
Pain is vital to humans because it signals that something is wrong. Pain is not a disease, but rather it’s an important warning sign to protect the body. But pain CAN be the result of Chronic diseases such as cancer and heart disease. Because Pain is something we experience, it's best measured by what you say it is.
Pain has an intensity; you can describe it on a scale from zero, no pain, to ten, the most pain imaginable. But pain also has a character,like sharp, dull, burning, or aching.
What exactly creates these perceptions of pain?
Well, when you get hurt, special tissue damage-sensing nerve cells, called nociceptors, fire and send signals to the spinal cord and then up to the brain. These are called pain signals.
The brain responds to these pain signals and has to cope with them in various ways. The most immediate being motor pathways are activated almost instantly to take your hand off a hot stove, for example. Also inflammatory cytokines trigger your blood vessels to dilate and increase blood flow, signaling immune cells, hormones and nutrients into the injury site to aid in healing.
Pain modulation networks are also activated that deliver endorphins and enkephalins, chemicals released when you're in pain or during extreme exercise, creating the runner's high or feelings of joy and happiness. For example laughter has also been proven to increase endorphins. Endorphins bind to opioid receptor sites and give us that feel good response that quells the pain and also helps to prevent further tissue damage. But the key idea here is the Body Can Make its Own Endorphins!
----
Chronic pain can interfere with your daily activities, such as working, having a social life and taking care of yourself or others. It can lead to depression, anxiety and trouble sleeping, which can make your pain worse. This response creates a cycle that’s difficult to break.
So anything that can help get rid of chronic pain naturally, safe and effectively- like PEMF therapy - can be a total life changing breakthrough if you have chronic pain as it can and does dramatically improve your quality of life!
---
Some of the MOST COMMON Sources of PAIN
When asked about four common types of pain, respondents of a National Institute of Health Statistics survey indicated that
1) low back pain was the most common (27%),
2) severe headache or migraine pain (15%),
3) neck pain (15%)
4) and facial ache or pain (4%). (mouth , teeth, jaw, eyes)
5) Joint Pain
6) Neuropathic Pain
7) Functional Pain
------
Conventional Medicine Approaches: heavy medication, procedures, surgeries, and physical therapy (physical therapy best acute pain).
Most people reach for a simple Numbing (like topical numbing creams and ice) and Dumbing approach to pain, like OTC, Prescriptions Opioids, or steroid injections and even antidepressents and sedatives/tranquilizers.
For mild pain, non-prescription medications OTC
can act on cells where the pain signals start. Examples are aspirin, acetominaphin (Tylenol) and ibuprofen (Advil), and naproxen - Nuh-praak-sin(Aleve).
For most this is not good enough. 16,000 Americans a year with arthritis alone die from gastric bleeding from nonsteroidal antiinflammatories like aspirin and ibuprofen. Thousands of others have permanent kidney damage from the NSAIDs.
Other stronger pain medicines and anesthetics work by reducing the activity in pain-sensing circuits or boosting our coping system, or endorphins. Oxycontin, Vicodine, Percoset and Morphine. (note Percoset and Vicodin both have acetominphin so double the issues.
It is these opioids that mimic endorphin that are such a problem that are incredibly addictive and have led to a nationwide Opioid crisis.
Opioid deaths have roughly quadrupled over the last ten years for which data is fully available. In 2021, the death toll surged to 80,411 and are currently at all time highs! Opiods are by far the leading cause of overdose in this country.
Fentanyl and other opioids are fueling the worst drug crisis in the history of the United States.
PANDEMIC: Opioid misuse increased almost unnoticed during the pandemic.
2022: opioids were responsible for about 20 percent of the approximately 6.3 million workers who were missing from the U.S. labor force, compared to prepandemic numbers.
Three Levels to this Problem which all started with the overprescription of legal drug medications.
1st Wave - OxyContin Purdue Pharma
Prescription Opioids for moderate to severe pain
It started in the mid-1990s when the powerful agent OxyContin, promoted by Purdue Pharma and approved by the Food and Drug Administration (FDA), triggered the first wave of deaths linked to use of legal prescription opioids. Claimed it was not addictive.
2nd Wave - Heroin Market
Then came a second wave of deaths from a heroin market that expanded to attract already addicted people.
Heroin - illegal Opioid. 36 people die every day from a Heroin Overdose.
Illegal Drug Cartels
3rd Wave - Fentanyl (synthetic opioid)
More recently, a third wave of deaths has arisen from illegal synthetic opioids like fentanyl. Fentanyl (synthetic opioid) [THE WORST] - many times more powerful that other opioids and is approved for treating severe pain, typically advanced cancer. Illegally distributed Fentanyl has been on the rise in several states.
Of all opioid deaths , over 82% where from synthetic opioids like fentanyl.
Illegal Drug Cartels
Worst side effect of opioids is troubled breathing which is what usually leads to death in overdose. Also headaches, nausea, trouble thinking, tiredness
----
Steroid and Cortisone Injections almost as bad
Steroid injections are the most commonly used procedures in conventional pain practice.
Damage tissue - pock marks - tissue melts away
Weight Gain
Puffiness Face
Diabetes worse
Damage to joints and tissues
Infection
If that doesn't work, than doctors will resort to surgery, which is very invasive and can have all sorts of complications. Even ablating the nerves, cutting the spinal cord and brain surgury.
We need a BETTER SOLUTION FOR PAIN and PEMF IS that research-proven, safe, effective and non-invasive solution to pain!! And remember with all these drugs and procedures, just because the pain is gone, does not mean the problem is gone!
Fentanyl and other opioids are fueling the worst drug crisis in the history of the United States.
PANDEMIC: Opioid misuse increased almost unnoticed during the pandemic.
2022: opioids were responsible for about 20 percent of the approximately 6.3 million workers who were missing from the U.S. labor force, compared to prepandemic numbers.
Three Levels to this Problem which all started with the overprescription of legal drug medications.
1st Wave - OxyContin Purdue Pharma
Prescription Opioids for moderate to severe pain
It started in the mid-1990s when the powerful agent OxyContin, promoted by Purdue Pharma and approved by the Food and Drug Administration (FDA), triggered the first wave of deaths linked to use of legal prescription opioids. Claimed it was not addictive.
2nd Wave - Heroin Market
Then came a second wave of deaths from a heroin market that expanded to attract already addicted people.
Heroin - illegal Opioid. 36 people die every day from a Heroin Overdose.
Illegal Drug Cartels
3rd Wave - Fentanyl (synthetic opioid)
More recently, a third wave of deaths has arisen from illegal synthetic opioids like fentanyl. Fentanyl (synthetic opioid) [THE WORST] - many times more powerful that other opioids and is approved for treating severe pain, typically advanced cancer. Illegally distributed Fentanyl has been on the rise in several states.
Of all opioid deaths , over 82% where from synthetic opioids like fentanyl.
Illegal Drug Cartels
Worst side effect of opioids is troubled breathing which is what usually leads to death in overdose. Also headaches, nausea, trouble thinking, tiredness
----
Steroid and Cortisone Injections almost as bad
Steroid injections are the most commonly used procedures in conventional pain practice.
Damage tissue - pock marks - tissue melts away
Weight Gain
Puffiness Face
Diabetes worse
Damage to joints and tissues
Infection
If that doesn't work, than doctors will resort to surgery, which is very invasive and can have all sorts of complications. Even ablating the nerves, cutting the spinal cord and brain surgury.
We need a BETTER SOLUTION FOR PAIN and PEMF IS that research-proven, safe, effective and non-invasive solution to pain!! And remember with all these drugs and procedures, just because the pain is gone, does not mean the problem is gone!
Before we get into the mechanisms of how PEMF helps with pain and the Protocols you can use (if you have a PEMF device), I first want to set the stage that PEMF therapy is VERY well proven to help with pain and evidence of why IT IS the best solution for natural pain relief.
\PEMF Research & FDA Approval
There are over 30,000 research papers showing the PEMFs help over 100 conditions! Not only that but PEMF therapy has FDA approval for several conditions like Non-union fractures, depression, pain and swelling and even brain cancer!!
The bodies own healing systems can get stuck. There is not enough energy in the body to create a bridging of that gap (say non union bone fractures). Research bassett early on show PEMF can stimulate electrical currents that can bridge the gap the body by itself could not.
There are over 30,000 research papers showing the PEMFs help over 100 conditions! Not only that but PEMF therapy has FDA approval for several conditions like Non-union fractures, depression, pain and swelling and even brain cancer!!
The bodies own healing systems can get stuck. There is not enough energy in the body to create a bridging of that gap (say non union bone fractures). Research bassett early on show PEMF can stimulate electrical currents that can bridge the gap the body by itself could not.
A randomized, double-blind, placebo-controlled clinical trial using a low- frequency magnetic field in the treatment of musculoskeletal chronic pain
A study was done by Alex Thomas and others of the Lawson research institute. In this study he and the research team used a low frequency and low intensity PEMF device that was attached to the brain (with two PEMF coils). In this study it was amazing how PEMF worked with pain relief.
In fact, they looked at how PEMF compared to several opioids like morphine, Vicodin, percoset and others. What they found was that PEMF therapy was the equivalent to a low dose of morphine (10 mg) for pain relief without the addiction or dependency! So if you lay on an effective PEMF therapy device, you are going to be getting an equivalent of a lose dose of morphine for pain relief!
Without Side Effects and Without Addictions.
*Thomas, A. W., K. Graham, et al. (2007). A randomized, double-blind, placebo-controlled clinical trial using a low- frequency magnetic field in the treatment of musculoskeletal chronic pain. Pain Res Manag 12(4): 249-58.
Thomas AW, Prato FS. Magnetic field based pain therapeutics and diagnostics. Bioelectromagnetics Society, 24th Annual Meeting, Quebec City, PQ, Canada, June, 2002
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670735/
A study was done by Alex Thomas and others of the Lawson research institute. In this study he and the research team used a low frequency and low intensity PEMF device that was attached to the brain (with two PEMF coils). In this study it was amazing how PEMF worked with pain relief.
In fact, they looked at how PEMF compared to several opioids like morphine, Vicodin, percoset and others. What they found was that PEMF therapy was the equivalent to a low dose of morphine (10 mg) for pain relief without the addiction or dependency! So if you lay on an effective PEMF therapy device, you are going to be getting an equivalent of a lose dose of morphine for pain relief!
Without Side Effects and Without Addictions.
*Thomas, A. W., K. Graham, et al. (2007). A randomized, double-blind, placebo-controlled clinical trial using a low- frequency magnetic field in the treatment of musculoskeletal chronic pain. Pain Res Manag 12(4): 249-58.
Thomas AW, Prato FS. Magnetic field based pain therapeutics and diagnostics. Bioelectromagnetics Society, 24th Annual Meeting, Quebec City, PQ, Canada, June, 2002
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670735/
Effectiveness of pulsed electromagnetic field therapy in lateral epicondylitis
Kaan Uzunca 1, Murat Birtane, Nurettin Taştekin
Kaan Uzunca 1, Murat Birtane, Nurettin Taştekin
More Randomized Clinical Trials on PEMF for Pain Management
1) Fibromyalgia
2) Osteoarthritis
3) Low Back Pain
4) CRPS - Complex Regional Pain Syndrome
5) Pelvic Pain
6) Tendinitis
7) Headaches and Migraines
8) Neuropathy, including Diabetic Neuropathy
9) Tennis Elbow and Elbow Pain
Another study on elbow pain, showed PEMF therapy worked BETTER than steroid injections and cortisone shots for pain and without the side effects!
1) Fibromyalgia
2) Osteoarthritis
3) Low Back Pain
4) CRPS - Complex Regional Pain Syndrome
5) Pelvic Pain
6) Tendinitis
7) Headaches and Migraines
8) Neuropathy, including Diabetic Neuropathy
9) Tennis Elbow and Elbow Pain
Another study on elbow pain, showed PEMF therapy worked BETTER than steroid injections and cortisone shots for pain and without the side effects!
Injury
Pain
Inflammatory Cascades - Neutrophils, Macrophages, Cytokines, iNOS
Proliferation/Circulation, Swelling
Wound Healing - Growth Factors/Fibroblasts/Stem Cells
Pain
Inflammatory Cascades - Neutrophils, Macrophages, Cytokines, iNOS
Proliferation/Circulation, Swelling
Wound Healing - Growth Factors/Fibroblasts/Stem Cells
1. Wound contraction is a dynamic process through which connective tissue matrix is formed by collagen fibers synthetized by newly migrated fibroblasts.Fibroblasts secrete collagen protein.
2. Granulation tissue is new connective tissue and microscopic blood vessels that form on the surfaces of a wound during the healing process.
3. Remodelling is the final phase of the healing process in which the granulation tissue matures into scar and tissue tensile strength is increased
2. Granulation tissue is new connective tissue and microscopic blood vessels that form on the surfaces of a wound during the healing process.
3. Remodelling is the final phase of the healing process in which the granulation tissue matures into scar and tissue tensile strength is increased
7 Research Proven Mechanisms Why the works SO GOOD for PAIN Relief, Inflammation, Swelling and Healing!
PEMFs heal tissues deep within the body when the correct intensity is used at the source of the pain. In PEMF therapy, low frequency pulses of electromagnetic stimulation is used to relieve pain and heal damaged tissues. These pulses activate energy at the cellular level to stimulate natural repair processes.
0) Calms Nociceptor Nerve Cells - Chronic pain is often perpetuated by abnormal, small nerve networks stuck in a rut of constant inflammation.
PEMFs heal tissues deep within the body when the correct intensity is used at the source of the pain. In PEMF therapy, low frequency pulses of electromagnetic stimulation is used to relieve pain and heal damaged tissues. These pulses activate energy at the cellular level to stimulate natural repair processes.
0) Calms Nociceptor Nerve Cells - Chronic pain is often perpetuated by abnormal, small nerve networks stuck in a rut of constant inflammation.
1) The second way PEMF helps with pain relief is by inducing and stimulating microcurrents in the tissues and especially neural pathways that transmit the signals of pain. These induced microcurrents in the neural pathways associated with the injured area interrupts PAIN signals in the nerves! And very simply, Less signal = less pain! This is a direct energetic mechanism for pain relief, and it is why microcurrents are prescribed by avant-garde doctors for pain relief (and remember PEMF induces microcurrents more deeply and less invasively so it is BETTER than microcurrent devices).
And Rapid Rise and Fall
And Rapid Rise and Fall
2) Magnetic Fields and PEMF Therapy naturally increase endorphins (endorphin = endogenous morphine) and enkaphalins , your body's natural opiates that make you FEEL GOOD and no pain. These compounds that come from the bodies natural pharmacy bind to opioid Receptors that BLOCK PAIN SIGNALS!
So we can actually produce these natural opiates to help with pain relief. And this is why the aforementioned study showed PEMF is just as effective as a low dose of morphine (without the side effects!). And the zero field studies (Hunt/Bunker Studies) we mentioned in lesson one showed that when we do NOT get the earth’s natural PEMF and magnetism, we start to feel pain for no reason. Why? Because the human body DEPENDS on the earth (at least partially) to stimulate natural endorphin release.
Dr. Nakagawa in his studied called fibromyalgia magnetic deficiency syndrome because lack of earth magnetism and PEMF can create the symptoms of pain experienced fibromyalgia patients or at least be a contributing cause. Of course the solution is vitamin P = PEMF!
The Two Fold Problem here is we spend 93% of our time inside and in cars, AND too much elecrosmog.
Valerie Hunt and Bunker Studies , pain for no reason... Magnetic Fields of Earth help to stimulate Endorphins!!!
So we can actually produce these natural opiates to help with pain relief. And this is why the aforementioned study showed PEMF is just as effective as a low dose of morphine (without the side effects!). And the zero field studies (Hunt/Bunker Studies) we mentioned in lesson one showed that when we do NOT get the earth’s natural PEMF and magnetism, we start to feel pain for no reason. Why? Because the human body DEPENDS on the earth (at least partially) to stimulate natural endorphin release.
Dr. Nakagawa in his studied called fibromyalgia magnetic deficiency syndrome because lack of earth magnetism and PEMF can create the symptoms of pain experienced fibromyalgia patients or at least be a contributing cause. Of course the solution is vitamin P = PEMF!
The Two Fold Problem here is we spend 93% of our time inside and in cars, AND too much elecrosmog.
Valerie Hunt and Bunker Studies , pain for no reason... Magnetic Fields of Earth help to stimulate Endorphins!!!
3) PEMF is Anti-inflammatory
In recent years, inflammation has come to the forefront of medical attention and has been recognized as the leading trigger of chronic pain and most major health disorders, including cardiovascular disease, diabetes, arthritis, Alzheimer's, and cancer. "All roads to chronic disease lead through inflammation," researchers are increasingly saying.
Reducing inflammation facilitates the optimal regeneration of damaged tissues and helps you not only symptomatically, but you will heal FASTER.
I tell people PEMF therapy is like BOTH Energetic "Heat" and "Ice" which helps to ice your pain like an ice pack with its anti-inflammatory effects and improve circulation and relax the muscles like heat does.
But unlike Ice, it does NOT constrict and reduce blood flow (which slows healing). And unlike Heat, it does not make inflammation flare up (which can increase pain).
With PEMF therapy, you get the best of both worlds and if you DO injure yourself, use PEMF RIGHT AWAY to reduce pain and speed up the healing process.
Proinflammatory Cytokines are produced predominately by activated M1 macrophages and are in involved in the upregulation of inflammatory reactions.
These cytokines are signaling proteins that help control inflammation in your body. They allow your immune system to mount a defense if germs or other substances that can make you sick enter your body. They are also involved in the healing and repair process following an injury. So Inflammation IS important... However it can sometimes stay turned on... Like an alarm that keeps going.
There are several peer reviewed research papers showing the PEMF reduce some of the most well known pro-inflammatory cytokines. It inhibits these pro-inflammatory cytokines through Adenosine receptors. Adenosine is a molecule that has been called a “guardian angel” in human disease. Working through the adenosine receptor (AR), adenosine plays a key role in controlling inflammation.
This overall net effect can dramatically reduce swelling and inflammation, which is why I sometimes call PEMF - energetic ice, but UNLIKE ice alone, PEMF ALSO stimulates growth factors and stem cells to promote healing and regeneration!
In recent years, inflammation has come to the forefront of medical attention and has been recognized as the leading trigger of chronic pain and most major health disorders, including cardiovascular disease, diabetes, arthritis, Alzheimer's, and cancer. "All roads to chronic disease lead through inflammation," researchers are increasingly saying.
Reducing inflammation facilitates the optimal regeneration of damaged tissues and helps you not only symptomatically, but you will heal FASTER.
I tell people PEMF therapy is like BOTH Energetic "Heat" and "Ice" which helps to ice your pain like an ice pack with its anti-inflammatory effects and improve circulation and relax the muscles like heat does.
But unlike Ice, it does NOT constrict and reduce blood flow (which slows healing). And unlike Heat, it does not make inflammation flare up (which can increase pain).
With PEMF therapy, you get the best of both worlds and if you DO injure yourself, use PEMF RIGHT AWAY to reduce pain and speed up the healing process.
Proinflammatory Cytokines are produced predominately by activated M1 macrophages and are in involved in the upregulation of inflammatory reactions.
These cytokines are signaling proteins that help control inflammation in your body. They allow your immune system to mount a defense if germs or other substances that can make you sick enter your body. They are also involved in the healing and repair process following an injury. So Inflammation IS important... However it can sometimes stay turned on... Like an alarm that keeps going.
There are several peer reviewed research papers showing the PEMF reduce some of the most well known pro-inflammatory cytokines. It inhibits these pro-inflammatory cytokines through Adenosine receptors. Adenosine is a molecule that has been called a “guardian angel” in human disease. Working through the adenosine receptor (AR), adenosine plays a key role in controlling inflammation.
This overall net effect can dramatically reduce swelling and inflammation, which is why I sometimes call PEMF - energetic ice, but UNLIKE ice alone, PEMF ALSO stimulates growth factors and stem cells to promote healing and regeneration!
Application of PEMF has been found to
4) PEMF has been research proven to increase GOOD Nitric Oxide (eNOS - endothelial) - As we saw in lesson 5, PEMF improves microcirculation significantly in the body. In injured and damaged tissues, PEMF helps to facilitate the excretion of acids, metabolic waste products and various debris from the injured area. This internal cleansing or flushing resulting from improved microcirculation also helps to remove the inflammatory enzymes, hormones and molecules which are the causes of triggering pain signaling pathways and nerve impulses. Also, from the improved microcirculation, PEMF Therapy helps the cells and tissues to access more oxygen and vital nutrients needed for energy, repair and rebuilding. Like after a car accident, clear the highway...
5) The next way that PEMF helps with pain relief is by improving lymphatic circulation and immunity so the body can heal and repair itself. By improving lymphatic flow and drainage, PEMF helps the body to transport macrophages, lymphocytes and antibodies into injured area which is the epicenter for pain signals.
6) The sixth and most important way PEMF helps with pain relief is by fixing the problem! Something our medical system CANNOT do... only numbing and dumbing.
This is most important, because PEMF helps the body to TRULY heal itself so the alarm of PAIN is no longer needed! Injured cells require approximately twice the energy as regular cells. And as we saw in Lesson 4, PEMF increases ATP and Cellular voltage so it has this essential energy needed to create new cells, divide, repair and heal! You don’t get that with drugs, injections or surgery. It is not just a numbing and dumbing effect like OTC and prescription drugs which do NOTHING to really stimulate the healing of the body. Unfortunately, partially because of PAIN, there is an opiate crisis in the U.S. If only PEMF therapy could be utilized more by doctors and hospitals, we could possibly see an end to this widespread problem!
The body needs energy to create new cells.
Robert O Becker and Regeneration - Healing is voltage and adult stem cells dedifferentiate into totipotent stem cells. Differentiation NOT a one way street contrary to developmental biology dogma.
Salamander keeps currents going.
More is not Better -- Student Frederick Brown. Lower current more stem cells.. Higher intensity did not work as well. You do not need high intensity. For healing and regeneration more is not better less is more.
7) Better Sleep - Healing and Repair... Harder to sleep when in pain ... #2 most common testimonial.
This is most important, because PEMF helps the body to TRULY heal itself so the alarm of PAIN is no longer needed! Injured cells require approximately twice the energy as regular cells. And as we saw in Lesson 4, PEMF increases ATP and Cellular voltage so it has this essential energy needed to create new cells, divide, repair and heal! You don’t get that with drugs, injections or surgery. It is not just a numbing and dumbing effect like OTC and prescription drugs which do NOTHING to really stimulate the healing of the body. Unfortunately, partially because of PAIN, there is an opiate crisis in the U.S. If only PEMF therapy could be utilized more by doctors and hospitals, we could possibly see an end to this widespread problem!
The body needs energy to create new cells.
Robert O Becker and Regeneration - Healing is voltage and adult stem cells dedifferentiate into totipotent stem cells. Differentiation NOT a one way street contrary to developmental biology dogma.
Salamander keeps currents going.
More is not Better -- Student Frederick Brown. Lower current more stem cells.. Higher intensity did not work as well. You do not need high intensity. For healing and regeneration more is not better less is more.
7) Better Sleep - Healing and Repair... Harder to sleep when in pain ... #2 most common testimonial.
**A2A receptors**
https://www.mdpi.com/1422-0067/22/2/809
A2A can be found in chondrocytes, synoviocytes, osteoblasts (in combination with A3A), dermal fibroblasts, keratinocytes, neutrophils, neurons, and endothelial cells, while A2B is expressed in keratinocytes and other epithelial
PEMF
Pulsed electromagnetic fields (PEMFs) are currently applied in the orthopedic field to promote reparative osteogenesis and to provide joint protection [8]. The first report describing the successful application of PEMFs to treat non-union fractures dates back to 1974 [9] and in 1979 the FDA approved PEMFs as a safe and effective treatment for nonunions, congenital pseudoarthrosis, and failed fusions. The scientific bases of PEMFs stimulation for bone healing lie on the identification of the relationship between electrical activity and bone formation in response to applied mechanical load by Fukada and Bassett [10,11].
PEMFs are low frequency magnetic fields, with a specific waveform and amplitude, characterized by a constant variation of the magnetic field amplitude over time. The pulsed magnetic field induces a secondary electric field in the exposed tissue similar to the one naturally generated during the transduction of mechanical energy into electrical energy [12]
Adenosine
Adenosine is a purine endogenous nucleoside with many physiopathological functions involved in cancer, pain, inflammation, and neurodegenerative diseases. Adenosine is primary synthesized from the dephosphorylation of ATP, ADP, and AMP, by the combined action of two hydrolyzing enzymes denominated ectonucleoside triphosphate diphosphohydrolase (CD39) and ecto-5′-nucleotidase (CD73) [18].
Conversely, A2A and A2BARs are coupled to Gs protein and their activation leads to an increase of cAMP [18]. ARs modulation is strongly implicated in the regulation of inflammatory processes suggesting their involvement in different pathologies resulting from inflammation, including many joint diseases [20].
The activation of A2AARs by endogenous adenosine controls the cartilage matrix homeostasis in physiological conditions [24]. The loss of A2AARs or CD73, in knockout mice, causes spontaneous osteoarthritis with modified cartilage composition and cartilage thinning [25,26]
PEMF increases A2A & Enhances Agonist to produce cAMP
The first report describing the effect of PEMFs on ARs dates back to 2002, when Varani et al. reported the upregulation of A2AARs induced by PEMFs exposure in human neutrophils [31]. Later, studies conducted on articular cells—such as chondrocytes and synoviocytes—reported that PEMFs treatment upregulates A2A and A3ARs expression (Figure 1) while having no effects on other AR subtypes [32]. The co-treatment with PEMFs and A2A and A3AR selective agonists, CGS21680 and Cl-IB-MECA respectively, showed an enhanced effect on the cAMP production in comparison to the agonist treatment alone. This suggests that PEMFs act as modulators able to enhance adenosine agonist activity.
The PEMFs treatment influences also the cellular growth of bovine chondrocytes and fibroblast-like synoviocytes: the co-treatment with CGS21680 and PEMFs significantly increases cell proliferation [32].
Other studies showed that A2A and A3ARs stimulation, in the presence of PEMFs, have anti-inflammatory effects decreasing PGE2 release and cyclooxygenase type 2 (COX-2) expression in bovine synovial fibroblasts [33]
treatment with A2A and A3AR agonists results in decreased release of pro-inflammatory cytokines such as tumor necrosis factor α (TNF-α), interleukin (IL) 8, PGE2, and IL-6 and increased production of the anti-inflammatory cytokine IL-10
*Anti-inflammatory* - no side effects, no receptor desensitization
In various in vitro studies, PEMFs stimulation demonstrated to be effective through the modulation of ARs and the subsequent reduction of inflammatory mediators release [81]. Interestingly, PEMFs through the increase of A2AARs and A3ARs potentiate the effect of endogenous adenosine resulting in more physiological effects in comparison to traditional drugs. As a consequence, the PEMF-enhanced anti-inflammatory effect of adenosine would not be accompanied by side effects, receptor desensitization, and downregulation [82]. These observations on adenosinergic system modulation suggest that PEMFs may represent an attractive strategy in the context of ‘soft-pharmacology’ as a non-invasive treatment capable of increasing the effect of an endogenous drug.
=== Varani ====
On the contrary the Bmax values of A2A adenosine
receptors present in human neutrophils are altered after 30 min
It is well known that a biological system exposed to a physical stimulus is able to detect its presence and to modify its own biological activity depending on the characteristics of the applied stimulus such as mechanic, electric or magnetic. The cell structure, able to receive the applied energy, has been identified to be cell membrane (Cadossi et al., 1992). In the past, it has been verified that electric or magnetic fields can aspect membrane functions not only by a local efect on ion fuxes or ligand binding, but also by altering the distribution and/or the aggregation of the intramembrane protein (Bersani et al., 1997).
Inflammation
Generally, it has been established that inflammation is characterized by massive infiltration of T lymphocytes, neutrophils and macrophages into the damaged tissue (Gessi et al., 2000). The available studies demonstrating the presence of A2A adenosine receptors in human neutrophils, strongly suggest that adenosine could play an important role in modulating immune and inflammatory processes and the activation of A2A receptors may have a relevant therapeutic potential (Cronstein et al., 1999; Montesinos et al., 2000)
Inflammation cont
It is known that neutrophils are the most abundant white cells in the peripheral blood and are usually the first cells to arrive at an injured or infected site. Adenosine, interacting with specific receptors on the surface of neutrophils, has been recognized as an endogenous anti-inflammatory agent (Cronstein, 1994). The activation of A2A receptors in human neutrophils affects the immune response in cancer, auto- immune and neurodegenerative diseases and decreases inflammatory reactions (Huang et al., 1997). Experimental evidence suggests that PEMFs are able to suppress the extravascular oedema during early inflammation (Lee et al., 1997).
It has also been demonstrated that the complete healing of wounds depends on the presence of A2A adenosine receptor agonists (Montesinos et al., 1997). In earlier studies, it has been reported that PEMFs mediate positive effects on a wound healing, controlling the proliferation of inflammatory lymphocytes and therefore demonstrating beneficial affects on inflammatory disease (Jasti et al., 2001).
1-3.5 mT
The experimental results revealed a dose-response relationship between the binding parameters of A2A adenosine receptors and the intensity of PEMFs reaching a stable plateau.
These results suggest a selective increase of responsiveness of the adenosine A2A receptor/adenylyl cyclase system in the presence of PEMF treatment
==>Upregulation can occur when there is an increase in the number of receptors on the cell surface, which makes the cells more sensitive to a hormone or other agent.
Moreover, PEMF treatment causes an increase of adenylyl cyclase activity and a reduction of superoxide anion production as a result of upregulation of the A2A receptors located on the neutrophil surface.
Adenylyl cyclase (AC) is an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP).
Although additional studies are needed to fully understand the relationship between adenosine-mediated anti-inflammatory effects44, 45 and PEMF expos
===Massari=====
A2A receptor (a G proteins, or guanine nucleotide-binding proteins) is like a molecular switch transmitting signals from outside the cell to inside the cell.
ATP/ADP -> AMP -> Adenosine -> A2A ->Adenylyl cyclase -> cAMP -> PKA (Protein Kinase) -> Nucleus -> CREB cAMP response element binding protein.
In the articular environment, the activity of inflammatory cells and pro-inflammatory cytokines can lead to degradation of the extracellular matrix and loss of proteoglycans, which compromises the mechanical competence of the cartilage. Once begun, cartilage loss accelerates through a combination of mechanical and biological events; therefore, it is of the utmost importance to prevent and limit the catabolic effect of inflammation of the articular cartilage (Fig. 1).
In 2002, Varani et al. observed a significant increase in binding of adenosine to the adenosine receptor subtype A2A in human neutrophils exposed to pulsed electromagnetic fields (p < 0.05).
Dose-response studies demonstrated that the effect was detectable after thirty minutes of exposure and saturation of the receptors was achieved with a magnetic field of 1.5 mT (Fig. 3). The effect of pulsed electromagnetic fields on adenosine binding with the A2A adenosine receptor was later confirmed in cultures of isolated fibroblast-like bo- vine synoviocytes and chondrocytes by the same group11 (Fig. 4). Together, these findings show that pulsed electro- magnetic fields have an A2A adenosine receptor agonist activ- ity, thereby identifying the A adenosine receptor as the pharmacological molecular target of therapeutic intervention with pulsed electromagnetic fields in patients with inflammatory joint diseases.
Bmax = receptor binding capacity
PEMF is an A2AR Agonist - a substance which initiates a physiological response when combined with a receptor.
Overall, the ex vivo data demonstrate that pulsed electro- magnetic fields stimulate anabolic activities in full-thickness cartilage explants and counteract the catabolic effect of the pro-inflammatory cytokine IL-1β
Pulsed electromagnetic fields have been used to treat un- united fractures for more than thirty years; nevertheless, to our knowledge, until now they never have been applied to the
joints of patients immediately after an arthroscopic procedure. The results of the preclinical studies reported above pro- vide a rational basis for the clinical use of pulsed electromag- netic fields to control inflammation and its catabolic effect on articular cartilage.
=====
Adenosine receptors are G-protein coupled receptors and particularly Gs-protein-coupled A2A and A2B adenosine receptors can increase intracellular cAMP levels by activating adenylate cyclase.
Pharmacological and biochemical studies established that A2AR are predominant subtype in immune cells [4, 6] and adenosine-A2AR interaction is capable of inhibiting inflammation by cAMP induction.
The anti-inflammatory effects of extracellular adenosine through adenosine receptor signaling has been known and investigated for a long time [7]. Others have shown that anti-inflammatory drugs, such as methotrexate, sulfasalazine and aspirin, exert their anti-inflammatory effects by triggering the accumulation of extracellular adenosine in tissues
A broad range of investigations using in vivo and/or in vitro approaches have provided evidence that A2A receptor activation limits inflammation and tissue damage, therefore playing an anti-inflammatory role [13, 31]. The A2A receptor signaling in suppressing inflammation is related to cAMP-increased levels, which also have a well-known immunosuppressive effect on immune cells.
the anti-inflammatory properties resulting from A2A receptor activation are due to the reduction of the release of inflammatory mediators such as IL-12, INFγ, TNF-α, and IL-4 from important immunomodulatory cells such as neutrophils, monocytes, dendritic cells and T lymphocytes
==>whereas the activation of A2AARs down-regulates ROS generation [35]
Because endogenous adenosine levels are elevated during an inflammatory process and endogenous adenosine can activate A2A receptors to attenuate inflammation and tissue damage, strategies that aim to foment adenosine production and increase its availability to activate A2A receptors present extraordinary anti-inflammatory potential.
A2A receptor (a G proteins, or guanine nucleotide-binding proteins) is like a molecular switch transmitting signals from outside the cell to inside the cell.
ATP/ADP -> AMP -> Adenosine -> A2A ->Adenylyl cyclase -> cAMP -> PKA (Protein Kinase) -> Nucleus -> CREB cAMP response element binding protein.
PEMF increases A2A receptors
===
It has been demonstrated that PEMFs have an agonist effect on A2A adenosine receptors, and this explains the anti- inflammatory effects observed in experimental [8,9,21] and clinical [10,11] studies.
These results support the rational basis for the use of PEMFs to control the inflammatory reaction that follows surgical procedures.
8. Varani K, Gessi S, Merighi S, Iannotta V, Cattabriga E, Spisani S, Cadossi R, Borea PA: Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils. Br J Pharmacol 2002, 136(1):57–66.
9. Varani K, De Mattei M, Vincenzi F, Gessi S, Merighi S, Pellati A, Ongaro A, Caruso A, Cadossi R, Borea PA: Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields. Osteoarthritis Cartilage 2008, 16(3):292–304.
10. Zorzi C, Dall'oca C, Cadossi R, Setti S: Effects of pulsed electromagnetic fields on patients' recovery after arthroscopic surgery: prospective, randomized and double-blind study. Knee Surg Sports Traumatol Arthrosc 2007, 15(7):830–834.
11. Benazzo F, Zanon G, Pederzini L, Modonesi F, Cardile C, Falez F, Ciolli L, La Cava F, Giannini S, Buda R, Setti S, Caruso G, Massari L: Effects of biophysical stimulation in patients undergoing arthroscopic reconstruction of anterior cruciate ligament: prospective, randomized and double blind study. Knee Surg Sports Traumatol Arthrosc 2008, 16(6):595–601.
21. De Mattei M, Pasello M, Pellati A, Stabellini G, Massari L, Gemmati D, Caruso A:
Effects of electromagnetic fields on proteoglycan metabolism of bovine
articular cartilage explants. Connect Tissue Res 2003, 44(3–4):154–159.
https://www.mdpi.com/1422-0067/22/2/809
A2A can be found in chondrocytes, synoviocytes, osteoblasts (in combination with A3A), dermal fibroblasts, keratinocytes, neutrophils, neurons, and endothelial cells, while A2B is expressed in keratinocytes and other epithelial
PEMF
Pulsed electromagnetic fields (PEMFs) are currently applied in the orthopedic field to promote reparative osteogenesis and to provide joint protection [8]. The first report describing the successful application of PEMFs to treat non-union fractures dates back to 1974 [9] and in 1979 the FDA approved PEMFs as a safe and effective treatment for nonunions, congenital pseudoarthrosis, and failed fusions. The scientific bases of PEMFs stimulation for bone healing lie on the identification of the relationship between electrical activity and bone formation in response to applied mechanical load by Fukada and Bassett [10,11].
PEMFs are low frequency magnetic fields, with a specific waveform and amplitude, characterized by a constant variation of the magnetic field amplitude over time. The pulsed magnetic field induces a secondary electric field in the exposed tissue similar to the one naturally generated during the transduction of mechanical energy into electrical energy [12]
Adenosine
Adenosine is a purine endogenous nucleoside with many physiopathological functions involved in cancer, pain, inflammation, and neurodegenerative diseases. Adenosine is primary synthesized from the dephosphorylation of ATP, ADP, and AMP, by the combined action of two hydrolyzing enzymes denominated ectonucleoside triphosphate diphosphohydrolase (CD39) and ecto-5′-nucleotidase (CD73) [18].
Conversely, A2A and A2BARs are coupled to Gs protein and their activation leads to an increase of cAMP [18]. ARs modulation is strongly implicated in the regulation of inflammatory processes suggesting their involvement in different pathologies resulting from inflammation, including many joint diseases [20].
The activation of A2AARs by endogenous adenosine controls the cartilage matrix homeostasis in physiological conditions [24]. The loss of A2AARs or CD73, in knockout mice, causes spontaneous osteoarthritis with modified cartilage composition and cartilage thinning [25,26]
PEMF increases A2A & Enhances Agonist to produce cAMP
The first report describing the effect of PEMFs on ARs dates back to 2002, when Varani et al. reported the upregulation of A2AARs induced by PEMFs exposure in human neutrophils [31]. Later, studies conducted on articular cells—such as chondrocytes and synoviocytes—reported that PEMFs treatment upregulates A2A and A3ARs expression (Figure 1) while having no effects on other AR subtypes [32]. The co-treatment with PEMFs and A2A and A3AR selective agonists, CGS21680 and Cl-IB-MECA respectively, showed an enhanced effect on the cAMP production in comparison to the agonist treatment alone. This suggests that PEMFs act as modulators able to enhance adenosine agonist activity.
The PEMFs treatment influences also the cellular growth of bovine chondrocytes and fibroblast-like synoviocytes: the co-treatment with CGS21680 and PEMFs significantly increases cell proliferation [32].
Other studies showed that A2A and A3ARs stimulation, in the presence of PEMFs, have anti-inflammatory effects decreasing PGE2 release and cyclooxygenase type 2 (COX-2) expression in bovine synovial fibroblasts [33]
treatment with A2A and A3AR agonists results in decreased release of pro-inflammatory cytokines such as tumor necrosis factor α (TNF-α), interleukin (IL) 8, PGE2, and IL-6 and increased production of the anti-inflammatory cytokine IL-10
*Anti-inflammatory* - no side effects, no receptor desensitization
In various in vitro studies, PEMFs stimulation demonstrated to be effective through the modulation of ARs and the subsequent reduction of inflammatory mediators release [81]. Interestingly, PEMFs through the increase of A2AARs and A3ARs potentiate the effect of endogenous adenosine resulting in more physiological effects in comparison to traditional drugs. As a consequence, the PEMF-enhanced anti-inflammatory effect of adenosine would not be accompanied by side effects, receptor desensitization, and downregulation [82]. These observations on adenosinergic system modulation suggest that PEMFs may represent an attractive strategy in the context of ‘soft-pharmacology’ as a non-invasive treatment capable of increasing the effect of an endogenous drug.
=== Varani ====
On the contrary the Bmax values of A2A adenosine
receptors present in human neutrophils are altered after 30 min
It is well known that a biological system exposed to a physical stimulus is able to detect its presence and to modify its own biological activity depending on the characteristics of the applied stimulus such as mechanic, electric or magnetic. The cell structure, able to receive the applied energy, has been identified to be cell membrane (Cadossi et al., 1992). In the past, it has been verified that electric or magnetic fields can aspect membrane functions not only by a local efect on ion fuxes or ligand binding, but also by altering the distribution and/or the aggregation of the intramembrane protein (Bersani et al., 1997).
Inflammation
Generally, it has been established that inflammation is characterized by massive infiltration of T lymphocytes, neutrophils and macrophages into the damaged tissue (Gessi et al., 2000). The available studies demonstrating the presence of A2A adenosine receptors in human neutrophils, strongly suggest that adenosine could play an important role in modulating immune and inflammatory processes and the activation of A2A receptors may have a relevant therapeutic potential (Cronstein et al., 1999; Montesinos et al., 2000)
Inflammation cont
It is known that neutrophils are the most abundant white cells in the peripheral blood and are usually the first cells to arrive at an injured or infected site. Adenosine, interacting with specific receptors on the surface of neutrophils, has been recognized as an endogenous anti-inflammatory agent (Cronstein, 1994). The activation of A2A receptors in human neutrophils affects the immune response in cancer, auto- immune and neurodegenerative diseases and decreases inflammatory reactions (Huang et al., 1997). Experimental evidence suggests that PEMFs are able to suppress the extravascular oedema during early inflammation (Lee et al., 1997).
It has also been demonstrated that the complete healing of wounds depends on the presence of A2A adenosine receptor agonists (Montesinos et al., 1997). In earlier studies, it has been reported that PEMFs mediate positive effects on a wound healing, controlling the proliferation of inflammatory lymphocytes and therefore demonstrating beneficial affects on inflammatory disease (Jasti et al., 2001).
1-3.5 mT
The experimental results revealed a dose-response relationship between the binding parameters of A2A adenosine receptors and the intensity of PEMFs reaching a stable plateau.
These results suggest a selective increase of responsiveness of the adenosine A2A receptor/adenylyl cyclase system in the presence of PEMF treatment
==>Upregulation can occur when there is an increase in the number of receptors on the cell surface, which makes the cells more sensitive to a hormone or other agent.
Moreover, PEMF treatment causes an increase of adenylyl cyclase activity and a reduction of superoxide anion production as a result of upregulation of the A2A receptors located on the neutrophil surface.
Adenylyl cyclase (AC) is an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP).
Although additional studies are needed to fully understand the relationship between adenosine-mediated anti-inflammatory effects44, 45 and PEMF expos
===Massari=====
A2A receptor (a G proteins, or guanine nucleotide-binding proteins) is like a molecular switch transmitting signals from outside the cell to inside the cell.
ATP/ADP -> AMP -> Adenosine -> A2A ->Adenylyl cyclase -> cAMP -> PKA (Protein Kinase) -> Nucleus -> CREB cAMP response element binding protein.
In the articular environment, the activity of inflammatory cells and pro-inflammatory cytokines can lead to degradation of the extracellular matrix and loss of proteoglycans, which compromises the mechanical competence of the cartilage. Once begun, cartilage loss accelerates through a combination of mechanical and biological events; therefore, it is of the utmost importance to prevent and limit the catabolic effect of inflammation of the articular cartilage (Fig. 1).
In 2002, Varani et al. observed a significant increase in binding of adenosine to the adenosine receptor subtype A2A in human neutrophils exposed to pulsed electromagnetic fields (p < 0.05).
Dose-response studies demonstrated that the effect was detectable after thirty minutes of exposure and saturation of the receptors was achieved with a magnetic field of 1.5 mT (Fig. 3). The effect of pulsed electromagnetic fields on adenosine binding with the A2A adenosine receptor was later confirmed in cultures of isolated fibroblast-like bo- vine synoviocytes and chondrocytes by the same group11 (Fig. 4). Together, these findings show that pulsed electro- magnetic fields have an A2A adenosine receptor agonist activ- ity, thereby identifying the A adenosine receptor as the pharmacological molecular target of therapeutic intervention with pulsed electromagnetic fields in patients with inflammatory joint diseases.
Bmax = receptor binding capacity
PEMF is an A2AR Agonist - a substance which initiates a physiological response when combined with a receptor.
Overall, the ex vivo data demonstrate that pulsed electro- magnetic fields stimulate anabolic activities in full-thickness cartilage explants and counteract the catabolic effect of the pro-inflammatory cytokine IL-1β
Pulsed electromagnetic fields have been used to treat un- united fractures for more than thirty years; nevertheless, to our knowledge, until now they never have been applied to the
joints of patients immediately after an arthroscopic procedure. The results of the preclinical studies reported above pro- vide a rational basis for the clinical use of pulsed electromag- netic fields to control inflammation and its catabolic effect on articular cartilage.
=====
Adenosine receptors are G-protein coupled receptors and particularly Gs-protein-coupled A2A and A2B adenosine receptors can increase intracellular cAMP levels by activating adenylate cyclase.
Pharmacological and biochemical studies established that A2AR are predominant subtype in immune cells [4, 6] and adenosine-A2AR interaction is capable of inhibiting inflammation by cAMP induction.
The anti-inflammatory effects of extracellular adenosine through adenosine receptor signaling has been known and investigated for a long time [7]. Others have shown that anti-inflammatory drugs, such as methotrexate, sulfasalazine and aspirin, exert their anti-inflammatory effects by triggering the accumulation of extracellular adenosine in tissues
A broad range of investigations using in vivo and/or in vitro approaches have provided evidence that A2A receptor activation limits inflammation and tissue damage, therefore playing an anti-inflammatory role [13, 31]. The A2A receptor signaling in suppressing inflammation is related to cAMP-increased levels, which also have a well-known immunosuppressive effect on immune cells.
the anti-inflammatory properties resulting from A2A receptor activation are due to the reduction of the release of inflammatory mediators such as IL-12, INFγ, TNF-α, and IL-4 from important immunomodulatory cells such as neutrophils, monocytes, dendritic cells and T lymphocytes
==>whereas the activation of A2AARs down-regulates ROS generation [35]
Because endogenous adenosine levels are elevated during an inflammatory process and endogenous adenosine can activate A2A receptors to attenuate inflammation and tissue damage, strategies that aim to foment adenosine production and increase its availability to activate A2A receptors present extraordinary anti-inflammatory potential.
A2A receptor (a G proteins, or guanine nucleotide-binding proteins) is like a molecular switch transmitting signals from outside the cell to inside the cell.
ATP/ADP -> AMP -> Adenosine -> A2A ->Adenylyl cyclase -> cAMP -> PKA (Protein Kinase) -> Nucleus -> CREB cAMP response element binding protein.
PEMF increases A2A receptors
===
It has been demonstrated that PEMFs have an agonist effect on A2A adenosine receptors, and this explains the anti- inflammatory effects observed in experimental [8,9,21] and clinical [10,11] studies.
These results support the rational basis for the use of PEMFs to control the inflammatory reaction that follows surgical procedures.
8. Varani K, Gessi S, Merighi S, Iannotta V, Cattabriga E, Spisani S, Cadossi R, Borea PA: Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils. Br J Pharmacol 2002, 136(1):57–66.
9. Varani K, De Mattei M, Vincenzi F, Gessi S, Merighi S, Pellati A, Ongaro A, Caruso A, Cadossi R, Borea PA: Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields. Osteoarthritis Cartilage 2008, 16(3):292–304.
10. Zorzi C, Dall'oca C, Cadossi R, Setti S: Effects of pulsed electromagnetic fields on patients' recovery after arthroscopic surgery: prospective, randomized and double-blind study. Knee Surg Sports Traumatol Arthrosc 2007, 15(7):830–834.
11. Benazzo F, Zanon G, Pederzini L, Modonesi F, Cardile C, Falez F, Ciolli L, La Cava F, Giannini S, Buda R, Setti S, Caruso G, Massari L: Effects of biophysical stimulation in patients undergoing arthroscopic reconstruction of anterior cruciate ligament: prospective, randomized and double blind study. Knee Surg Sports Traumatol Arthrosc 2008, 16(6):595–601.
21. De Mattei M, Pasello M, Pellati A, Stabellini G, Massari L, Gemmati D, Caruso A:
Effects of electromagnetic fields on proteoglycan metabolism of bovine
articular cartilage explants. Connect Tissue Res 2003, 44(3–4):154–159.
I will be giving you protocols for using PEMF for pain relief , especially the three most common sources of pain. Low back pain is the most common source. That is 27% of the people who have pain problems. There’s a tie for second; severe headaches or migraines (about 15%), and neck pain (also about 15%). Between low back pain, severe headaches and migraines, and neck pain well over 50% of all sources of pain are accounted for. I’m going to give you some practical advice you can use to get rid of pain once and for all.
But First, Let me guide on what to look for in a PEMF therapy device before we get into the protocols. That way the protocols will make more sense. You want to look for a whole body mat system with local applicators. It's nice to have a system with a split mode that allows you to use two applicators at once.
1. Coils (Speakers / Antenna of a PEMF system) - Circular, Large Full Body
2. Intensity and Flux - The BIG LIE - Use Biosavart
Demonstration with Mic Mag Handy.
Magnetic Flux Example - OMI vs iMRS
- Just Loud Enough like Classical
Signal - Heartbeat, Music of PEMF
3. Rapid Rise and Fall - Stimulate Healing Microcurrents / Becker
Faraday Induction is the Key NOT INTENSITY!!
Intensity + Area + Speed of Induction
4. Repetition Rate / Circadian Rhythm
Frequency for Non-sinusoidal signals
Listen to Pillow Pad
5. Spectral Content and Tissue Resonances
Broad Spectrum like good multi-vitamin
Spectrum Analyzer
6. Pulsetrain Complexity - prevent habituation
7. Quality, Don't Settle for Cheap Chinese Alibaba
8. Good Applicators and Accessories, not gimmicks
9. SAFE - ICNIRP
But First, Let me guide on what to look for in a PEMF therapy device before we get into the protocols. That way the protocols will make more sense. You want to look for a whole body mat system with local applicators. It's nice to have a system with a split mode that allows you to use two applicators at once.
1. Coils (Speakers / Antenna of a PEMF system) - Circular, Large Full Body
2. Intensity and Flux - The BIG LIE - Use Biosavart
Demonstration with Mic Mag Handy.
Magnetic Flux Example - OMI vs iMRS
- Just Loud Enough like Classical
Signal - Heartbeat, Music of PEMF
3. Rapid Rise and Fall - Stimulate Healing Microcurrents / Becker
Faraday Induction is the Key NOT INTENSITY!!
Intensity + Area + Speed of Induction
4. Repetition Rate / Circadian Rhythm
Frequency for Non-sinusoidal signals
Listen to Pillow Pad
5. Spectral Content and Tissue Resonances
Broad Spectrum like good multi-vitamin
Spectrum Analyzer
6. Pulsetrain Complexity - prevent habituation
7. Quality, Don't Settle for Cheap Chinese Alibaba
8. Good Applicators and Accessories, not gimmicks
9. SAFE - ICNIRP
Protocols
Protocols for Back, Neck, and Joint Pain
According to research from the University of North Carolina at Chapel Hill, no less than 84% of adults in the U.S. will experience chronic back pain at some point in their life.
At any given moment about 15% people are experiencing back pain. Back pain is associated with over-exertion, heavy lifting, but it can also be the result of inactivity, and poor posture. It can also develop progressively due to arthritis, osteoporosis, or normal wear and tear.
Back pain has become an epidemic in the United States, and it is a leading cause of disability and lost productivity in the workplace today.
Full Body Mat, then Pillow or local applicator over low back. Medium to high level.
Use a pillow pad for low back pain for 16 minutes, 2-3 times a day (more is OK for severe or acute pain). Use the 150-200% level. That’s a higher intensity, roughly in the 40-50 micro-tesla range. Here are some sample placements of the pillow pad for sitting down or laying down. You could be reading a book or watching TV while you are speeding up the healing.
Use ice 15-20 minutes while the pain is severe.
Decompress on Stomach!
According to research from the University of North Carolina at Chapel Hill, no less than 84% of adults in the U.S. will experience chronic back pain at some point in their life.
At any given moment about 15% people are experiencing back pain. Back pain is associated with over-exertion, heavy lifting, but it can also be the result of inactivity, and poor posture. It can also develop progressively due to arthritis, osteoporosis, or normal wear and tear.
Back pain has become an epidemic in the United States, and it is a leading cause of disability and lost productivity in the workplace today.
Full Body Mat, then Pillow or local applicator over low back. Medium to high level.
Use a pillow pad for low back pain for 16 minutes, 2-3 times a day (more is OK for severe or acute pain). Use the 150-200% level. That’s a higher intensity, roughly in the 40-50 micro-tesla range. Here are some sample placements of the pillow pad for sitting down or laying down. You could be reading a book or watching TV while you are speeding up the healing.
Use ice 15-20 minutes while the pain is severe.
Decompress on Stomach!
**Chronic Joint Pain**
Joint pain, typically caused by injury, infection, or advancing age, is one of the leading types of chronic pain among American adults.
According to a report from the U.S. Bone and Joint Initiative, arthritis is the most common cause, affecting over 51 million Americans (or roughly one of every two adults).
Joint pain, typically caused by injury, infection, or advancing age, is one of the leading types of chronic pain among American adults.
According to a report from the U.S. Bone and Joint Initiative, arthritis is the most common cause, affecting over 51 million Americans (or roughly one of every two adults).
Chronic Headaches
According to research, 50% of the adult population will report headaches during the course of a year, while more than 90% will report a lifetime history of headaches.
Protocols for Headaches/Migraines
According to the National Headache Foundation over 45-million Americans suffer from chronic, recurring headaches. Of these, 28-million suffer from migraines, also called chronic daily headaches or chronic, non-progressive headaches. Tension headaches are the most common type of headaches among adults and adolescents. These muscles contraction headaches cause mild to moderate pain and come and go over long periods of time. Migraine pain is moderate to severe, often described as pounding throbbing pain. Migraines can last from four hours to several days, and usually occur from one to four times a month. Migraines are associated with symptoms such as sensitivity to light, noise or odors, nausea or vomiting, loss of appetite, stomach upset or abdominal pain. The exact cause of migraines is unknown but a popular theory is that very triggers cause abnormal brain activity which in turn changes the blood vessels in the brain. That’s called the neurovascular theory. According to one Harvard researcher and headache expert, many migraine headaches may have evolved if neck related muscle tension headaches were not successfully addressed earlier in life. Along with PEMF therapy, chiropractic adjustment and massage, proper diet and exercise really help with migraines.
Here are the protocols for headaches and migraines, based on the German research. They recommend using the full body mat for 8 minutes, 2-4 times a day. Level 25 in the morning and level 10 in the afternoon, and the sensitive setting at night. Use the pillow pad on the head area 1-2 times daily, at level 25-50. For migraines you can also use the probe for 24 minutes for 1-2 times daily, at level 100-150. Use the probe on the temple for acupuncture and local treatment.
According to research, 50% of the adult population will report headaches during the course of a year, while more than 90% will report a lifetime history of headaches.
Protocols for Headaches/Migraines
According to the National Headache Foundation over 45-million Americans suffer from chronic, recurring headaches. Of these, 28-million suffer from migraines, also called chronic daily headaches or chronic, non-progressive headaches. Tension headaches are the most common type of headaches among adults and adolescents. These muscles contraction headaches cause mild to moderate pain and come and go over long periods of time. Migraine pain is moderate to severe, often described as pounding throbbing pain. Migraines can last from four hours to several days, and usually occur from one to four times a month. Migraines are associated with symptoms such as sensitivity to light, noise or odors, nausea or vomiting, loss of appetite, stomach upset or abdominal pain. The exact cause of migraines is unknown but a popular theory is that very triggers cause abnormal brain activity which in turn changes the blood vessels in the brain. That’s called the neurovascular theory. According to one Harvard researcher and headache expert, many migraine headaches may have evolved if neck related muscle tension headaches were not successfully addressed earlier in life. Along with PEMF therapy, chiropractic adjustment and massage, proper diet and exercise really help with migraines.
Here are the protocols for headaches and migraines, based on the German research. They recommend using the full body mat for 8 minutes, 2-4 times a day. Level 25 in the morning and level 10 in the afternoon, and the sensitive setting at night. Use the pillow pad on the head area 1-2 times daily, at level 25-50. For migraines you can also use the probe for 24 minutes for 1-2 times daily, at level 100-150. Use the probe on the temple for acupuncture and local treatment.
Chronic Nerve Pain
Chronic nerve (neuropathic) pain affects one of every 10 Americans,6 according to a study from the Mayo Clinic School of Medicine. This commonly happens when the nerves are either compressed, damaged, or exposed to drugs that strip their protective exterior coating (called the myelin sheath).
Sciatica, Diabetic Neuropathy, Carpal Tunnel
Chronic nerve (neuropathic) pain affects one of every 10 Americans,6 according to a study from the Mayo Clinic School of Medicine. This commonly happens when the nerves are either compressed, damaged, or exposed to drugs that strip their protective exterior coating (called the myelin sheath).
Sciatica, Diabetic Neuropathy, Carpal Tunnel
ALSO BRAIN - Centralization - Chronic Pain can centralize Quickly in the Brain..
Functional Pain - Pain that has no known cause. Common in fibromyalgia.
Functional Pain - Pain that has no known cause. Common in fibromyalgia.
How can I achieve the best results?
- Drink a lot of water - 2 glasses (16 oz.) 15-30 minutes before a session. This is CRITICAL for success! Drink at least 8 glasses a water or half your body weight in ounces a day.
- Alkalize the body. Try fresh lemon in water in the morning. Eat Alkaline, Antiinflammatory Diet. Avoid Sugar. refined carbohydrates, fried foods, processed foods, fast foods, soft drinks and sodas. Stick to whole foods: fruits (especially berries), dark green veggies, had a big salad at least once a day, steamed veggies, whole grains, beans, legumes, soups, and small amounts of chicken, turkey, eggs and dairy (grass fed butter best option). There is no need to be fanatical, listen to your body and eat only when hungry. Get in touch with true hunger.
- Deliberate deep abdominal breathing during treatment
- Add a good multivitamin (I like Dr Fuhrman's) and
- other supplements that help with pain, swelling and inflammation such as systemic enzymes, tumeric, ginger, boswellia (and other anti-inflammatory herbs), bromlein, omega 3 fatty acids and astaxanthin, resveratrol, Vitamin C, MSM, vitamin D, and magnesium.
- Smile and Laugh More -- Laugter increases endorphins.
- Correct settings on equipment (read this guide carefully)... Use high intensity PEMF only under guidance of a trained practitioner. MORE is not better. The human body is very subtle and natural earth frequenices and intensities are ideal. Use finesse not force. More is not better, BETTER is BETTER.
- Regular Use - USE IT EVERY DAY! 2x a day for at least 8 minutes!
- In addition to PEMF, chiropractic and massage is recommended. I recommend chiropractors associated with www.idealspine.com because they will help with correct posture and lifestyle changes in addition to good adjustments and basic chiropractic care. Blair Upper Cervical.
- Rehab, Exercise - Make it strong again!
- Posture, Sit-Stand Desk, Lay on Stomach, Kneeling Chair, Interrupt sitting!